It is 12:05 p.m. in your Resuscitation Bay.
A 58-year-old man was brought in after collapsing at a wedding dinner shortly after eating shellfish.
He has a history of hypertension and migraine prophylaxis treated with celiprolol 200 mg once daily.
He has already received in the ED:
Two IM adrenaline 500 µg (1:1000) 5 min apart
3 L Hartmann’s IV fluid
IV hydrocortisone 200 mg + chlorphenamine 10 mg
Adrenaline infusion titrated to 2 mL/kg/h (max rate reached)
Noradrenaline infusion added via central line
Current status (30 min after starting dual infusions):
He remains pale, cold, confused, with thready pulses.
HR 56 bpm BP 68/36 mmHg RR 30 SpO₂ 91 % (15 L O₂)
ABG: pH 7.29 / PaCO₂ 5.1 kPa / Lactate 7.4 mmol/L
Capillary refill > 5 s despite full resuscitation.
What is the most appropriate next pharmacologic intervention?